Huge study: 5 mental disorders share genetic links


WASHINGTON (AP) — The largest genetic study of mental illnesses to date finds five major disorders may not look much alike but they share some gene-based risks. The surprising discovery comes in the quest to unravel what causes psychiatric disorders and how to better diagnose and treat them.


The disorders — autism, attention deficit-hyperactivity disorder or ADHD, bipolar disorder, major depressive disorder and schizophrenia — are considered distinct problems. But findings published online Wednesday suggest they're related in some way.


"These disorders that we thought of as quite different may not have such sharp boundaries," said Dr. Jordan Smoller of Massachusetts General Hospital, one of the lead researchers for the international study appearing in The Lancet.


That has implications for learning how to diagnose mental illnesses with the same precision that physical illnesses are diagnosed, said Dr. Bruce Cuthbert of the National Institute on Mental Health, which funded the research.


Consider: Just because someone has chest pain doesn't mean it's a heart attack; doctors have a variety of tests to find out. But there's no blood test for schizophrenia or other mental illnesses. Instead, doctors rely on symptoms agreed upon by experts. Learning the genetic underpinnings of mental illnesses is part of one day knowing if someone's symptoms really are schizophrenia and not something a bit different.


"If we really want to diagnose and treat people effectively, we have to get to these more fine-grained understandings of what's actually going wrong biologically," Cuthbert explained.


Added Mass General's Smoller: "We are still in the early stages of understanding what are the causes of mental illnesses, so these are clues."


The Psychiatric Genomics Consortium, a collaboration of researchers in 19 countries, analyzed the genomes of more than 61,000 people, some with one of the five disorders and some without. They found four regions of the genetic code where variation was linked to all five disorders.


Of particular interest are disruptions in two specific genes that regulate the flow of calcium in brain cells, key to how neurons signal each other. That suggests that this change in a basic brain function could be one early pathway that leaves someone vulnerable to developing these disorders, depending on what else goes wrong.


For patients and their families, the research offers no immediate benefit. These disorders are thought to be caused by a complex mix of numerous genes and other risk factors that range from exposures in the womb to the experiences of daily life.


"There may be many paths to each of these illnesses," Smoller cautioned.


But the study offers a lead in the hunt for psychiatric treatments, said NIMH's Cuthbert. Drugs that affect calcium channels in other parts of the body are used for such conditions as high blood pressure, and scientists could explore whether they'd be useful for psychiatric disorders as well.


The findings make sense, as there is some overlap in the symptoms of the different disorders, he said. People with schizophrenia can have some of the same social withdrawal that's so characteristic of autism, for example. Nor is it uncommon for people to be affected by more than one psychiatric disorder.


___


Online:


http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)60223-8/abstract


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Long-shot candidate's provocative video gains attention









No one has accused Los Angeles mayoral candidate Kevin James of lacking for showmanship. His spirited debate performances have given an outsize profile to the onetime talk radio host's long-shot campaign.


But the financially strapped candidate's release of a Web video showing his rivals as burying a dead body in a shallow grave has set off accusations that James has overreached in trying to draw attention to himself in the last days before the Tuesday primary.


The James video depicts top contenders Wendy Greuel and Eric Garcetti as part of a culture of corruption at City Hall. Actors playing the city controller and city councilman bury a body in the dead of night — an effigy for the public funds the duo has allegedly wasted.





Neither Greuel nor Garcetti has faced charges of malfeasance. And their rival's claim that Los Angeles operates a particularly corrupt city government is not borne out by an academic study the James camp cites as proof.


But James stood by his contention that the two city officials have been corrupt because, he charges, they helped redirect funds for parking, fire hydrants and to purposes not supported by the public. James campaign manager Jeff Corless said the waste included "outrageous salaries and pensions [of] public employees, whose unions back their campaigns to the tune of millions of dollars."


Campaign observers said James was relying on the over-the-top imagery and ominous undertones of the video to stir up the mayoral contest.


"It's a stunt," Parke Skelton, a veteran Los Angeles political consultant, said of the nearly two-minute video.


"It's a common tactic to try to generate press attention in a race where you don't have the funds to compete for voters in any other way," said Skelton, who is not aligned with any of the candidates in the race. "You can do something extremely provocative to get attention, but it doesn't necessarily help your campaign."


The James spot plays off the frequent claim by Greuel, the city controller, that she would be the best mayor because she has investigated city agencies and knows "where the bodies are buried." That's because, James retorts, Greuel "helped bury them."


James, the lone Republican in the field, accused Greuel and Garcetti of "raiding" special city funds to help close budget gaps created by their mismanagement. The money went to cover employee raises, pension costs, "redecorated offices" and "handouts to special interests," James charges.


City officials have defended transfers into the city's general fund as a stop-gap measure to pay for crucial services, including Police and Fire Department operations, when tax receipts took a sharp downward turn during the Great Recession.


James's opponents belittled the video.


"If the Kevin James campaign falls in a forest, can anyone hear it? With 209 views on YouTube, the only people seeing Kevin James' ad is Kevin James," said Greuel's chief strategist, John Shallman.


After speaking at a mayoral forum on education Wednesday along with James and other candidates, Garcetti laughed about the video. "I told Kevin, 'We're going to bury you. We're going to bury the competition,' " Garcetti said.


With less than $25,000 cash on hand the last time campaign totals were reported, James has few options to draw attention to himself. (An independent campaign group, however, has spent more than $658,000 to air television and radio ads on James's behalf.) The new spot appeared to be garnering just the kind of "free" media attention that campaigns hope for when they release such videos.


At least three local television affiliates jumped on the story. CNN had a camera at the news conference when the campaign released the video, which it dubbed "Buried." KFI radio, Reuters and other outlets followed suit.


One of the claims in the ad is that "corruption is the way of life in City Hall, making L.A. one of the most corrupt regions in America."


Corless previously said that the notion of Los Angeles as a hotbed of corruption came, in part, from a study released last year by researchers at the University of Illinois. But the James campaign misconstrues what that research found.


The statistics in the Illinois study come not from the city of L.A. but from the federal judiciary's Central District of California. That includes seven counties with more than 18 million residents, making it by far the most populous federal jurisdiction in America, said Thom Mrozek, a spokesman for the U.S. attorney's office in Los Angeles.


The entire region ranks high in total corruption convictions in large part because it encompasses so many government employees. The Illinois study did not break out per capita rates of corruption by region, but it did for entire states. By that measure, California ranked 35th in number of convictions for public corruption over the years of the study. The "leaders" in the most corrupt derby were the District of Columbia, Louisiana, Illinois, New York and Pennsylvania.


Officials in the U.S. attorney's office (where James, now an entertainment attorney, once worked) said they can remember only a few recent criminal cases against Los Angeles city employees.


Three former building and safety inspectors have been convicted of taking bribes in a probe that began in 2010. A former official of the Housing Authority got 51 months in prison last year for diverting more than $500,000 to a sham company he set up with his brothers.


Los Angeles City Councilman Richard Alarcon has been accused of using a false address for electoral purposes. That case is pending.


James' camp said other corruption cases prosecuted by the district attorney bolster the notion of trouble at City Hall.


Political scientist Dick Simpson of the University of Illinois, one of the authors of the corruption study, said the worst abuses tended to be not in Southern California but in other parts of the country.


"You essentially have in Los Angeles a reform city," Simpson said. "The places with the most corruption, like Chicago and New Orleans, come out of machine politics. You don't have the same thing out there."


james.rainey@latimes.com


seema.mehta@latimes.com





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Shimon Peres to Press Obama to Release Jonathan Pollard



JERUSALEM (AP) — President Shimon Peres of Israel said on Tuesday that he would lead an effort during President Obama’s coming visit to press for the release of the convicted spy Jonathan Pollard, ending one of the most painful episodes between the two allies.


Mr. Pollard was sentenced to life in prison in 1987 for passing classified material to Israel. He is said to be in poor health, and his case has become a rallying cry in Israel.


But stiff opposition from the American military and intelligence community has deterred a string of American presidents from releasing him.


More than 65,000 Israelis have signed a petition calling on Mr. Obama to free Mr. Pollard, the Facebook page of the United States Embassy in Israel has been flooded with pardon requests, and a nationwide campaign began urging Mr. Peres to push for Mr. Pollard’s release.


Mr. Peres said he would raise the issue in a meeting with Mr. Obama, calling for Mr. Pollard’s release “on humanitarian grounds.”


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Bobby Brown Sentenced to 55 Days in Jail in Drunk Driving Case















02/26/2013 at 09:30 PM EST



Bobby Brown has been sentenced to 55 days in jail and four years probation in his most recent drunk driving arrest.

Brown, 44, was pulled over in Studio City, Calif., on Oct. 24 for driving erratically and was arrested when the officer detected "a strong scent of alcohol." He was charged with DUI and driving on a suspended license.

He was also arrested for driving under the influence in March of 2012.

Brown pled no contest to the charges on Tuesday, reports TMZ. He was also ordered to complete an 18-month alcohol treatment program.

The singer, who married Alicia Etheredge in Hawaii in June of 2012, must report to jail by March 20.

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Advanced breast cancer edges up in younger women


CHICAGO (AP) — Advanced breast cancer has increased slightly among young women, a 34-year analysis suggests. The disease is still uncommon among women younger than 40, and the small change has experts scratching their heads about possible reasons.


The results are potentially worrisome because young women's tumors tend to be more aggressive than older women's, and they're much less likely to get routine screening for the disease.


Still, that doesn't explain why there'd be an increase in advanced cases and the researchers and other experts say more work is needed to find answers.


It's likely that the increase has more than one cause, said Dr. Rebecca Johnson, the study's lead author and medical director of a teen and young adult cancer program at Seattle Children's Hospital.


"The change might be due to some sort of modifiable risk factor, like a lifestyle change" or exposure to some sort of cancer-linked substance, she said.


Johnson said the results translate to about 250 advanced cases diagnosed in women younger than 40 in the mid-1970s versus more than 800 in 2009. During those years, the number of women nationwide in that age range went from about 22 million to closer to 30 million — an increase that explains part of the study trend "but definitely not all of it," Johnson said.


Other experts said women delaying pregnancy might be a factor, partly because getting pregnant at an older age might cause an already growing tumor to spread more quickly in response to pregnancy hormones.


Obesity and having at least a drink or two daily have both been linked with breast cancer but research is inconclusive on other possible risk factors, including tobacco and chemicals in the environment. Whether any of these explains the slight increase in advanced disease in young women is unknown.


There was no increase in cancer at other stages in young women. There also was no increase in advanced disease among women older than 40.


Overall U.S. breast cancer rates have mostly fallen in more recent years, although there are signs they may have plateaued.


Some 17 years ago, Johnson was diagnosed with early-stage breast cancer at age 27, and that influenced her career choice to focus on the disease in younger women.


"Young women and their doctors need to understand that it can happen in young women," and get checked if symptoms appear, said Johnson, now 44. "People shouldn't just watch and wait."


The authors reviewed a U.S. government database of cancer cases from 1976 to 2009. They found that among women aged 25 to 39, breast cancer that has spread to distant parts of the body — advanced disease — increased from between 1 and 2 cases per 100,000 women to about 3 cases per 100,000 during that time span.


The study was published Tuesday in the Journal of the American Medical Association.


About one in 8 women will develop breast cancer in their lifetime, but only 1 in 173 will develop it by age 40. Risks increase with age and certain gene variations can raise the odds.


Routine screening with mammograms is recommended for older women but not those younger than 40.


Dr. Len Lichtenfeld, the American Cancer Society's deputy chief medical officer, said the results support anecdotal reports but that there's no reason to start screening all younger women since breast cancer is still so uncommon for them.


He said the study "is solid and interesting and certainly does raise questions as to why this is being observed." One of the most likely reasons is probably related to changes in childbearing practices, he said, adding that the trend "is clearly something to be followed."


Dr. Ann Partridge, chair of the federal Centers for Disease Control and Prevention's advisory committee on breast cancer in young women, agreed but said it's also possible that doctors look harder for advanced disease in younger women than in older patients. More research is needed to make sure the phenomenon is real, said Partridge, director of a program for young women with breast cancer at the Harvard-affiliated Dana-Farber Cancer Institute.


The study shouldn't cause alarm, she said. Still, Partridge said young women should be familiar with their breasts and see the doctor if they notice any lumps or other changes.


Software engineer Stephanie Carson discovered a large breast tumor that had already spread to her lungs; that diagnosis in 2003 was a huge shock.


"I was so clueless," she said. "I was just 29 and that was the last thing on my mind."


Carson, who lives near St. Louis, had a mastectomy, chemotherapy, radiation and other treatments and she frequently has to try new drugs to keep the cancer at bay.


Because most breast cancer is diagnosed in early stages, there's a misconception that women are treated, and then get on with their lives, Carson said. She and her husband had to abandon hopes of having children, and she's on medical leave from her job.


"It changed the complete course of my life," she said. "But it's still a good life."


____


Online:


JAMA: http://jama.ama-assn.org


CDC: http://www.cdc.gov/cancer/breast/index.htm


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Deasy group aids 3 school board candidates









Los Angeles schools Supt. John Deasy isn't on the ballot Tuesday, but you'd hardly know it, based on the undercurrent of the school board election.


A coalition of local organizations, wealthy donors and L.A. Mayor Antonio Villaraigosa have decided that the election is all about keeping Deasy on the job and accelerating the aggressive policies he's putting into place.


This group has come together for the campaign through a political action committee called the Coalition for School Reform. So far it's raised on behalf of three candidates more than $3.2 million, including $1 million from New York City Mayor Michael Bloomberg.





The superintendent has a "relentless focus on improving student performance, rather than on protecting a system that does not always serve students," said Elise Buik, president of the United Way of Greater Los Angeles. And that, she said, "has made him an easy target for those who are comfortable with the status quo."


Although not part of the funding coalition, the United Way is allied with community groups that support Deasy and want to limit the influence of the teachers union.


That union, United Teachers Los Angeles, is opposing the coalition in two of these races and is neutral in the third. Unless national unions jump in massively, UTLA cannot match the coalition in dollars, but it does have thousands of volunteers it can mobilize including teachers, counselors, social workers and librarians.


UTLA has not made removing Deasy a litmus test for candidates it supports — and Deasy has worked successfully with all employee unions on notable issues — but a sizable UTLA contingent says Deasy has misplaced priorities that have denigrated teachers and worsened working conditions.


Deasy, and the groups that support him, place a high priority on improving teacher effectiveness through new performance reviews that rely on student standardized test scores as a key component. Deasy has proposed basing 30% of an instructor's evaluation on test scores; the teachers union opposes such a fixed percentage.


Many Deasy backers also would end teacher job protections that protect ineffective veteran instructors at the expense of more able teachers with less seniority. So far, Deasy has limited, but not ended, the seniority system, which is enshrined in state law. The union defends seniority as the fairest approach to layoffs, especially in the absence of an evaluation system that they find reliable.


The superintendent also has sped the dismissal process of teachers accused of misconduct and pushed for changes in state law that would give him more authority over hiring and firing.


Advocates for independently managed charter schools have made common cause with the coalition. They oppose impediments to the growth and operation of charters and also want freer access to district-owned campuses. L.A. Unified has the greatest number of publicly funded charter schools of any district in the country.


The tenure of the schools chief, who has been praised by the Obama administration, has become more precarious in recent months because three of the seven current members of the Board of Education would consider removing him, according to insiders. None of the three are on the ballot in the March 5 election.


That has intensified the focus on the reelection bid of one-term incumbent Steve Zimmer, 42, who is supported by the teachers union. Zimmer talks of Deasy as a strong leader with whom he sometimes has strong disagreements; he has been unwilling to replace Deasy so far. But the superintendent's supporters see Zimmer as a possible fourth anti-Deasy vote. Zimmer's District 4 stretches from the Westside to the west San Fernando Valley.


Zimmer's backers insist that he simply does not deserve to be fired by voters. They describe the longtime teacher and neighborhood activist as a thoughtful, hardworking moderate who helped bring opposing parties together on issues large and small.


The pro-Deasy forces are firmly behind challenger Kate Anderson, 41, who leaves no doubt about her enthusiasm for the superintendent.


Her supporters say the board could use her intelligence and perspective. They point to her experience in civic affairs, including as an attorney, a parent, a onetime congressional staffer, a member of a neighborhood council and even her stint as UCLA student body president.


The coalition also stands firmly behind school board President Monica Garcia, 44, a Deasy backer who is considered Villaraigosa's closest ally on the board. Her District 2 stretches out from downtown.


Thanks to the coalition and her own sway within the district, Garcia enjoys a dominant funding advantage over all four challengers combined. The union hasn't bankrolled any challenger but has invested in an anti-Garcia campaign, hoping to force a runoff.


Her challengers are: Robert Skeels, 47, a writer and researcher who criticizes corporate and foundation involvement in education as well as the growth of standardized testing; Isabel Vazquez, 52, a former board member's aide who became an adult-school administrator before budget cuts forced her return to the classroom this year; Abelardo Diaz, 51, a veteran Spanish teacher, who helped start a bilingual academic decathlon and is among the founding faculty at the Cortines School of Visual and Performing Arts; and Annamarie Montanez, 40, a teacher with broad experience at the elementary and adult-school levels, reduced to part-time hours in the adult school because of budget cuts.


Board member Nury Martinez is leaving her District 6 seat after one term to run for L.A. City Council. Her district encompasses the east San Fernando Valley.


Among three candidates, Antonio Sanchez, 30, voiced the clearest support for Deasy, a major factor in his landing financial support from the coalition. Non-teaching unions also have spent money in support of Sanchez, who just completed a master's degree in urban planning at UCLA. He has experience in campaign work and as a staff member for a state legislator and the mayor.


Another aspirant is Maria Cano, 42, a veteran manager in the community outreach office of the district's school construction program; the wind-down of that effort resulted in her being laid off. The third candidate is Monica Ratliff, 43, a veteran fifth-grade teacher at a high-performing school who worked as an attorney before deciding to change fields.


The teachers union has funded no candidate in this contest.


howard.blume@latimes.com



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Video Shows French Family’s Kidnappers Are Nigerian Extremists





LAGOS, Nigeria — A French family kidnapped last week on the Cameroon-Nigeria border appeared on a video posted Monday on YouTube, with one of the hostages and a gunman saying that the family is being held by the Nigerian Islamist extremist group Boko Haram.




The family members — three adults and four children — are shown sitting on the ground inside a sort of tent made from prayer mats, in front of a black Qaeda-style banner, grim-faced but apparently in good health. The children, boys ages 5 to 12, fidget and glance at the camera. The family is flanked by two masked, fatigues-wearing men holding rifles, and in front of them s another masked hostage taker, who reads out a statement in Arabic demanding the release of “brothers” and “sisters” and threatening twice to “slaughter those we took” unless the group’s demands are met.


The French military campaign against Islamist militants in Mali is obliquely referred to by the masked gunman, who says “the president of France” has “waged war against Islam.”


Before that, a man identified by the French media as Tanguy Moulin-Fournier, the children’s father, reads a statement in French saying the family was “arrested” by Boko Haram. He uses the group’s Arabic name — it means “those engaged in the propagation and teaching of the prophet and of jihad” — which is responsible for hundreds of killings in a three-year insurgency in Nigeria’s north.


Next to him are a woman, apparently his wife, and a man, his brother; his wife is wearing a black head covering.


On Monday evening, French officials, including Prime Minister Jean-Marc Ayrault, identified the kidnappers as members of Boko Haram, with Foreign Minister Laurent Fabius calling the video “terribly shocking.”


But the link to Boko Haram remained unproven Monday night. The video differs from others released by the group in that Hausa, the language of Nigeria’s north, is not spoken on it, and Boko Haram had not previously been associated with kidnapping Westerners or showing them on videos. In addition, purported members of Boko Haram denied, in a statement to Nigerian journalists over the weekend, involvement in the kidnapping.


Mr. Moulin-Fournier, an expatriate employee of the French gas group GDF Suez, was vacationing with his family at a national park in northern Cameroon near the border with Nigeria when they were seized early last Tuesday by motorcycle-riding gunmen. Cameroon officials said the hostages were then taken across the border to Nigeria to the area that gave birth to Boko Haram nearly four years ago and where it is strongest, Borno State.


The group has waged a relentless guerrilla campaign of bombings and ambushes there and across northern Nigeria, which killed some 800 people last year alone. Its goals, beyond spreading mayhem and undermining the Nigerian state, remain vague, though it has demanded the establishment of Shariah law in Nigeria.


While Boko Haram claimed responsibility for the deadly 2011 bombing of the United Nations headquarters in Abuja, Nigeria’s capital, the group has focused mostly on Nigerian targets, which would make the kidnapping of the French family something of a departure. In the video, apart from the admonishment to “the president of France,” the masked gunman warns President Goodluck Jonathan of Nigeria that “we will establish the Islamic state of Nigeria.”


The gunman tells Mr. Jonathan in Arabic, according to the SITE Monitoring Service: “We say to you: If you want us to leave those French people, leave all of our women whom you imprisoned by your hands quickly, because we know that all ways of disbelief are the same, and all of you are equally in war with us.”


The gunman also warns the president of Cameroon to release Boko Haram members — the gunman uses that informal name for the group — though none is known to be held by that country.


Though kidnapping has not so far been part of Boko Haram’s campaign, it has figured in that of a splinter group, Ansaru, known to be holding a number of Western hostages.


Nigerian officials declined to comment on the video Monday night and have said almost nothing about the kidnapping. The French, however, reiterated their belief that the family is being held in Nigeria, not Cameroon.


Scott Sayare contributed reporting from Paris.



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The Bachelor's Sean Lowe Reveals Final Two






The Bachelor










02/25/2013 at 10:30 PM EST







From left: AshLee, Lindsay and Catherine


Kevin Foley/ABC(3)


And then there were two.

After three incredible dates in Thailand with the remaining women, The Bachelor's Sean Lowe faced a difficult decision at the end of Monday's episode: Would he send home AshLee, Catherine or Lindsay?

Keep reading to find out who got a rose – and who was left heartbroken ...

Sean said goodbye to early favorite AshLee in a surprising elimination that left her virtually speechless.

Visibly upset, AshLee left Sean's side without saying goodbye. She even asked him to not walk her to the waiting car that would take her away.

But Sean did get to explain. "I thought it was you from the very beginning," he said. "This was honestly the hardest decision I've ever had to make ... I think the world of you. I did not want to hurt you."

"This wasn't a silly game for me," AshLee said as the car drove away. "This wasn't about a joy ride. It wasn't about laughing and joking and having fun."

She added: "It's hard to say goodbye to Sean because I let him in ... It's the ultimate [rejection]."

Check back Tuesday morning for Sean Lowe's blog post to read all about his Thailand dates and why he chose to send AshLee home

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Koop, who transformed surgeon general post, dies


With his striking beard and starched uniform, former Surgeon General Dr. C. Everett Koop became one of the most recognizable figures of the Reagan era — and one of the most unexpectedly enduring.


His nomination in 1981 met a wall of opposition from women's groups and liberal politicians, who complained President Ronald Reagan selected Koop, a pediatric surgeon and evangelical Christian from Philadelphia, only because of his conservative views, especially his staunch opposition to abortion.


Soon, though, he was a hero to AIDS activists, who chanted "Koop, Koop" at his appearances but booed other officials. And when he left his post in 1989, he left behind a landscape where AIDS was a top research and educational priority, smoking was considered a public health hazard, and access to abortion remained largely intact.


Koop, who turned his once-obscure post into a bully pulpit for seven years during the Reagan and George H.W. Bush administrations and who surprised both ends of the political spectrum by setting aside his conservative personal views on issues such as homosexuality and abortion to keep his focus sharply medical, died Monday at his home in Hanover, N.H. He was 96.


An assistant at Koop's Dartmouth College institute, Susan Wills, confirmed his death but didn't disclose its cause.


Dr. Richard Carmona, who served as surgeon general a decade ago under President George W. Bush, said Koop was a mentor to him and preached the importance of staying true to the science even if it made politicians uncomfortable.


"He set the bar high for all who followed in his footsteps," Carmona said.


Although the surgeon general has no real authority to set government policy, Koop described himself as "the health conscience of the country" and said modestly just before leaving his post that "my only influence was through moral suasion."


A former pipe smoker, Koop carried out a crusade to end smoking in the United States; his goal had been to do so by 2000. He said cigarettes were as addictive as heroin and cocaine. And he shocked his conservative supporters when he endorsed condoms and sex education to stop the spread of AIDS.


Chris Collins, a vice president of amFAR, the Foundation for AIDS Research, said many people don't realize what an important role Koop played in the beginning of the AIDS epidemic.


"At the time, he really changed the national conversation, and he showed real courage in pursuing the duties of his job," Collins said.


Even after leaving office, Koop continued to promote public health causes, from preventing childhood accidents to better training for doctors.


"I will use the written word, the spoken word and whatever I can in the electronic media to deliver health messages to this country as long as people will listen," he promised.


In 1996, he rapped Republican presidential hopeful Bob Dole for suggesting that tobacco was not invariably addictive, saying Dole's comments "either exposed his abysmal lack of knowledge of nicotine addiction or his blind support of the tobacco industry."


Although Koop eventually won wide respect with his blend of old-fashioned values, pragmatism and empathy, his nomination met staunch opposition.


Foes noted that Koop traveled the country in 1979 and 1980 giving speeches that predicted a progression "from liberalized abortion to infanticide to passive euthanasia to active euthanasia, indeed to the very beginnings of the political climate that led to Auschwitz, Dachau and Belsen."


But Koop, a devout Presbyterian, was confirmed after he told a Senate panel he would not use the surgeon general's post to promote his religious ideology. He kept his word.


In 1986, he issued a frank report on AIDS, urging the use of condoms for "safe sex" and advocating sex education as early as third grade.


He also maneuvered around uncooperative Reagan administration officials in 1988 to send an educational AIDS pamphlet to more than 100 million U.S. households, the largest public health mailing ever.


Koop personally opposed homosexuality and believed sex should be saved for marriage. But he insisted that Americans, especially young people, must not die because they were deprived of explicit information about how HIV was transmitted.


Koop further angered conservatives by refusing to issue a report requested by the Reagan White House, saying he could not find enough scientific evidence to determine whether abortion has harmful psychological effects on women.


Koop maintained his personal opposition to abortion, however. After he left office, he told medical students it violated their Hippocratic oath. In 2009, he wrote to Senate Majority Leader Harry Reid, urging that health care legislation include a provision to ensure doctors and medical students would not be forced to perform abortions. The letter briefly set off a security scare because it was hand delivered.


Koop served as chairman of the National Safe Kids Campaign and as an adviser to President Bill Clinton's health care reform plan.


At a congressional hearing in 2007, Koop spoke about political pressure on the surgeon general post. He said Reagan was pressed to fire him every day, but Reagan would not interfere.


Koop, worried that medicine had lost old-fashioned caring and personal relationships between doctors and patients, opened his institute at Dartmouth to teach medical students basic values and ethics. He also was a part-owner of a short-lived venture, drkoop.com, to provide consumer health care information via the Internet.


Koop was born in the New York City borough of Brooklyn, the only son of a Manhattan banker and the nephew of a doctor. He said by age 5 he knew he wanted to be a surgeon and at age 13 he practiced his skills on neighborhood cats.


He attended Dartmouth, where he received the nickname Chick, short for "chicken Koop." It stuck for life.


Koop received his medical degree at Cornell Medical College, choosing pediatric surgery because so few surgeons practiced it.


In 1938, he married Elizabeth Flanagan, the daughter of a Connecticut doctor. They had four children, one of whom died in a mountain climbing accident when he was 20.


Koop was appointed surgeon-in-chief at Children's Hospital in Philadelphia and served as a professor at the University of Pennsylvania School of Medicine.


He pioneered surgery on newborns and successfully separated three sets of conjoined twins. He won national acclaim by reconstructing the chest of a baby born with the heart outside the body.


Although raised as a Baptist, he was drawn to a Presbyterian church near the hospital, where he developed an abiding faith. He began praying at the bedside of his young patients — ignoring the snickers of some of his colleagues.


Koop's wife died in 2007, and he married Cora Hogue in 2010.


He was by far the best-known surgeon general and for decades afterward was still a recognized personality.


"I was walking down the street with him one time" about five years ago, recalled Dr. George Wohlreich, director of the College of Physicians of Philadelphia, a medical society with which Koop had longstanding ties. "People were yelling out, 'There goes Dr. Koop!' You'd have thought he was a rock star."


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Ring reported from Montpelier, Vt. Cass reported from Washington. AP Medical Writers Lauran Neergaard in Washington and Mike Stobbe in New York contributed to this report.


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